Isaac Clarke is the main protagonist of the highly acclaimed Dead Space game series. PewDiePie has so far done Let's Plays on Dead Space 2 and Dead Space 3 Demo.
Whenever Pewds is in a hairy situation with the necromorphs, he will try to cheer Issac on by saying 'Go Isaac! Go Isaac!'. PewDiePie also does this cheer in The Binding of Isaac.
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